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In the nucleus, NRF2 binds to antioxidant response elements (ARE) in the promoter regions of its target genes, leading to the transcription of genes that mitigate oxidative damage, support cellular redox balance, and enhance survival mechanisms (Lou et al., 2021)

These modifications have been hypothesized to play a crucial role in the diffusion of DNA damage response/senescence-associated secretory phenotype (DDR/SAPS) signaling to non-damaged surrounding cells during aging, suggesting that DDR/SASP signaling components may contribute to the development of novel therapeutic interventions against age-related diseases (Olivieri et al., 2015)

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Henretig FM, Selbst SM, Forrest C, et al

Findings here Findings here Findings here Findings here It Is considered a specific symptomatic remedy for hyperthyroidism because it is known to slow thyroid function by reducing production of TSH